Pfas Chemicals: A Comprehensive List Of Known Compounds

Per- and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals that have been widely used in various industrial and consumer applications for decades. These compounds have gained significant attention due to their persistence in the environment and potential health risks. The family of PFAS chemicals is vast, and many compounds have been identified and studied. This article aims to provide a comprehensive list of known PFAS compounds, along with an in-depth analysis of their characteristics, uses, and potential impacts.
Understanding the PFAS Family

PFAS chemicals are characterized by their unique chemical structure, which includes a carbon-fluorine bond. This bond is one of the strongest in organic chemistry, making PFAS highly stable and resistant to degradation. This stability, while beneficial for certain applications, has led to environmental concerns as PFAS can persist in the environment for extended periods.
The PFAS family can be broadly categorized into two main groups: long-chain and short-chain PFAS. Long-chain PFAS, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), have been the subject of extensive research and regulatory attention due to their persistence and potential health effects. Short-chain PFAS, on the other hand, have gained interest as potential alternatives to their long-chain counterparts.
The Comprehensive List of Known PFAS Compounds

The following is a detailed list of some of the most well-known and studied PFAS compounds, along with their key characteristics and uses:
Perfluorooctanoic Acid (PFOA)
Chemical Formula: C8H7F15O2
Uses: PFOA was widely used in the production of various consumer goods, including non-stick cookware, waterproof clothing, and food packaging. It was also a processing aid in the manufacture of fluoropolymers.
Health Concerns: Studies have linked PFOA exposure to various health issues, including developmental and reproductive problems, liver damage, and an increased risk of certain cancers. PFOA is designated as a “likely human carcinogen” by the International Agency for Research on Cancer (IARC).
Perfluorooctane Sulfonate (PFOS)
Chemical Formula: C8H17F17O3S
Uses: PFOS has been utilized in a wide range of applications, including fire-fighting foams, surfactants, and coatings for textiles and paper. It was also a key component in the manufacturing of certain electronic devices.
Environmental Impact: PFOS is highly persistent in the environment and can bioaccumulate in living organisms. It has been detected in various environmental media, including water, soil, and wildlife. Its presence in the food chain has raised concerns about potential human exposure.
GenX Chemicals
Chemical Formula: C8H12F10O2
Uses: GenX chemicals are a group of compounds developed as an alternative to PFOA in the production of fluoropolymers. They are used in the manufacture of non-stick coatings, as well as in semiconductor and photovoltaic industries.
Health and Environmental Concerns: While GenX chemicals were designed to be less persistent than PFOA, studies have suggested potential health risks. Research is ongoing to better understand their environmental fate and potential impacts on human health.
Perfluorobutane Sulfonate (PFBS)
Chemical Formula: C4H9F13O3S
Uses: PFBS is a short-chain PFAS compound used as a replacement for PFOS in various applications. It is found in fire-fighting foams, metal plating, and as a surfactant in industrial processes.
Environmental Behavior: PFBS is considered more environmentally friendly than long-chain PFAS due to its shorter carbon chain. However, it still exhibits persistence and mobility in the environment, and its long-term effects are under investigation.
Perfluorobutyrate (PFBA)
Chemical Formula: C3H5F7O2
Uses: PFBA is a short-chain PFAS used in various applications, including as a processing aid in the manufacture of fluoropolymers and as a component in pharmaceuticals.
Health and Safety: PFBA is considered less toxic than long-chain PFAS, but its potential health effects are still being studied. It has been detected in environmental samples, and its fate and transport in the environment are subjects of ongoing research.
Perfluorobutanesulfonamide (PFBSA)
Chemical Formula: C4H9F13NO3S
Uses: PFBSA is a short-chain PFAS used in the production of surfactants and as a component in various industrial processes.
Environmental Presence: PFBSA has been detected in wastewater and surface water, indicating its release into the environment. Its environmental behavior and potential impacts on ecosystems are areas of active research.
Perfluorinated Carboxylic Acids (PFCAs)
Chemical Formula: CnF2n+1COOH (where n represents the number of carbon atoms)
Uses: PFCAs are a group of long-chain PFAS compounds with various applications, including in the production of non-stick coatings, fire-fighting foams, and as surfactants.
Health and Environmental Concerns: PFCAs, such as PFOA and PFNA, have been linked to adverse health effects in humans and wildlife. Their persistence and bioaccumulation potential have led to regulatory actions and phased-out production in many regions.
Performance and Environmental Analysis
PFAS compounds have been valued for their unique performance characteristics, including their ability to repel water and oil, their chemical stability, and their low surface tension. These properties have made them ideal for a wide range of applications, from industrial processes to consumer products.
However, the very attributes that make PFAS useful have also contributed to their environmental persistence and potential health risks. The stability of the carbon-fluorine bond means that PFAS compounds can resist degradation by natural processes, leading to their accumulation in the environment. This persistence has resulted in the detection of PFAS in various environmental media, including water, soil, and even remote locations such as the Arctic.
The environmental fate of PFAS compounds is complex. While some PFAS can be transported long distances through air and water, others can bind to soil particles and accumulate in sediment. PFAS can also bioaccumulate in living organisms, including fish, birds, and mammals, raising concerns about their potential entry into the food chain.
The environmental impact of PFAS extends beyond their persistence and bioaccumulation. PFAS compounds have been linked to various ecological effects, including endocrine disruption, reproductive issues, and immune system suppression in wildlife. Additionally, the presence of PFAS in water sources has raised concerns about potential human exposure through drinking water and contaminated food.
Regulatory and Industry Responses
The growing awareness of the potential risks associated with PFAS has prompted regulatory actions and industry responses worldwide. Many countries and regions have implemented measures to restrict the use and production of certain PFAS compounds, particularly long-chain PFAS like PFOA and PFOS.
In the United States, the Environmental Protection Agency (EPA) has established health advisories for certain PFAS, including PFOA and PFOS, to provide guidance on acceptable levels in drinking water. The EPA has also developed a PFAS Action Plan, which outlines strategies to address PFAS contamination and support research on PFAS behavior and health effects.
Internationally, the Stockholm Convention on Persistent Organic Pollutants (POPs) has listed PFOS and its salts for global elimination, with exemptions for specific uses. Additionally, the European Union has restricted the use of certain PFAS in consumer products and established maximum concentration limits for PFAS in drinking water.
The industry has also taken steps to address PFAS concerns. Some companies have phased out the use of long-chain PFAS and invested in the development of alternative compounds. However, the transition to safer alternatives is a complex process, as many short-chain PFAS may still exhibit persistence and potential health risks.
Future Implications and Research Directions

The comprehensive understanding of PFAS compounds and their potential impacts is an ongoing area of research. Scientists and regulators are working to fill knowledge gaps and develop strategies to mitigate PFAS-related risks.
Key research directions include:
- Environmental Fate and Transport: Studying the behavior of PFAS in various environmental media, including their mobility, degradation, and bioaccumulation potential.
- Health Effects: Conducting further research to understand the health impacts of PFAS exposure, particularly for short-chain and emerging PFAS compounds.
- Remediation Technologies: Developing effective methods to remove PFAS from contaminated sites and water sources.
- Alternative Compounds: Evaluating the safety and performance of alternative PFAS and non-PFAS compounds to ensure they are less harmful to human health and the environment.
As the body of knowledge on PFAS continues to grow, it is essential for regulatory bodies, industries, and the public to stay informed and engaged in addressing the challenges posed by these chemicals. The comprehensive list provided in this article serves as a starting point for further exploration and understanding of the diverse PFAS family.
What are the primary sources of PFAS exposure for humans?
+Humans can be exposed to PFAS through various pathways, including contaminated drinking water, food (especially fish and meat from animals exposed to PFAS), and consumer products containing PFAS. Occupational exposure is also a concern for workers in industries that use PFAS.
Are there any PFAS-free alternatives for consumer products?
+Yes, there are PFAS-free alternatives available for certain consumer products. For example, non-fluorinated coatings can be used in cookware, and water-repellent fabrics can be made without PFAS. However, it is important to note that some alternatives may have their own environmental and health considerations.
How can I reduce my exposure to PFAS in my daily life?
+Reducing exposure to PFAS involves several steps: drinking water from a known safe source, avoiding the use of non-stick cookware, opting for PFAS-free personal care products, and being cautious when using products that may contain PFAS (e.g., stain-resistant treatments or fire-fighting foams). Regularly checking for PFAS contamination in your area and following local guidance is also recommended.